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Clinical Studies

Nasa Scientist Ray Cronise Proves Science Of Fat Freezing At TEDMED 2010

After a 20 year struggle to manage his weight and remain fit, Ray developed some unique insights on the body’s ability to burn calories and applied some basic thermodynamic principles, ultimately losing — and keeping off — over 50 pounds of excess body fat.

arms before and after
Fat process

1. Lim, Dr. Adrian, 2014, Cryolipolysis with a double-applicator 3-dimensional cooling cup device, Royal North Shore Hospital, uRepublic Cosmetic Dermatology, and Veins NSW Australia


The following results are from a Clinical Study conducted by Royal North Shore Hospital specifically on CLATUU.

“In one study with 42 patients, 79% noticed fat reduction on themselves at 2-4 months. Another study with 50 patients, 89% showed a noticeable improvement in photography with a similar proportion (80%) being happy with the results at 6 months”.

Our study showed no adverse effects associated with CLATUU cryolipolysis. Our subjects experienced an initial ‘suction’ discomfort lasting 5-10 minutes followed by cold-induced numbness for the rest of the procedure. The most common post-treatment effect was numbness lasting from 1 to 3 weeks. One patient with atopic dermatitis experienced mild itching over the treated site for a few days post-cryolipolysis.

* Results vary from person to person due to family history, age, and different skin types.

Female abs

2. Manstein et al, 2008, Selective Cryolysis: A Novel Method of Non-Invasive Fat Removal, Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, Lasers in Surgery and Medicine 40:595–604

Excess fat poses a host of local and systemic problems. Various energy sources, for example, laser, ultrasound, and radio frequency electric current have been studied as potential non-invasive treatments aimed at local destruction of subcutaneous fat. This study describes non-invasive cold-induced selective destruction of subcutaneous fat.

Conclusion: “Prolonged, controlled local skin cooling can induce selective damage and subsequent loss of subcutaneous fat, without damaging the overlying skin. Typically there was no clinical or histological evidence of injury to the skin and no scarring”.

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Woman measuring her belly fat with her hands close up

4. Krueger et al. 2014, Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction, Clinical, Cosmetic and Investigational Dermatology 2014:7 201–205

Conclusion: “In clinical studies, cryolipolysis was shown to reduce subcutaneous fat at the treatment site by up to 25% after one treatment. Improvements were seen in 86% of treated subjects”.

Woman’s body before and after weight loss

5. Mathew M. Avram, MD, JD1 and Rosemary S. Harry, MSBME2 1, Cryolipolysis for Subcutaneous Fat Layer Reduction, Dermatology Laser & Cosmetic Center, Massachusetts General Hospital, Boston, Massachusetts.

Conclusion: “Cryolipolysis has demonstrated efficacy in both human and animal studies. Histology findings also confirm the selective reduction of fat in both humans and animals, with evidence of a gradual thinning of the fat layer over a period of two to four months. Importantly, cryolipolysis has not produced any significant adverse side effects in studies to date”.

Ice Blue Snowflake

6. Kim, J et al, 2014, Clinical effectiveness of non-invasive selective cryolipolysis, Journal of Cosmetic and Laser Therapy

Conclusion: “In clinical studies, cryolipolysis was shown to reduce subcutaneous fat at the treatment site by up to 25% after one treatment. Improvements were seen in 86% of treated subjects”

Fat Freezing vs Non Surgical Body Sculpting

7. Ingargiola et al, 2015, Cryolipolysis for Fat Reduction and Body Contouring Safety and Efficacy of Current Treatment Paradigms, Division of Plastic and Reconstructive Surgery, Mount Sinai Hospital; Department of Plastic Surgery, Loma Linda University, American Society of Plastic Surgeons

Conclusion: “Cryolipolysis is a promising procedure for nonsurgical fat reduction and body contouring and presents a compelling alternative to liposuction and other, more invasive methods. This procedure appears to be safe in the short term, with a limited side effect profile, and results in significant fat reduction when used for localized adiposities”

Learn more about our Medical Grade Technology

Watch the videos below

Evidence Based Protocols for Cryo Fat Reduction 1:14

Learn more about our Gold Standard Medical Grade technology in this video, the non-invasive, no downtime, strong and powerful natural body contouring treatment.

Plastic Surgery Hub 1:30

Trish Hammond from Plastic Surgery Hub, discusses the technology and benefits of Cryolipolysis in this short video to help you understand how the technology helps to reduce fat deposits in otherwise hard to treat areas.

Cryolipolysis Explained 1:44

This video explains in details how medical grade technology, destroys fat cells which are chilled using a controlled cooling system to the point where the body’s natural “apoptosis” processes are triggered, gradually collecting these damaged fat cells and eliminating them from the body.