Clinical and Scientific Studies

Nasa Scientist Ray Cronise Proves Science Of Fat Freezing At TEDMED 2010

After a 20-year struggle to manage his weight and remain fit, Ray developed some unique insights on the body’s ability to burn calories and applied some basic thermodynamic principles, ultimately losing — and keeping off — over 50 pounds of excess body fat.

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Watch the videos below

Evidence Based Protocols for Cryo Fat Reduction 1:14

Learn more about our Gold Standard Medical Grade technology in this video, the non-invasive, no downtime, strong and powerful natural body contouring treatment.

Plastic Surgery Hub 1:30

Trish Hammond from Plastic Surgery Hub, discusses the technology and benefits of Cryolipolysis in this short video to help you understand how the technology helps to reduce fat deposits in otherwise hard to treat areas.

Cryolipolysis Explained 1:44

This video explains in details how medical grade technology, destroys fat cells which are chilled using a controlled cooling system to the point where the body’s natural “apoptosis” processes are triggered, gradually collecting these damaged fat cells and eliminating them from the body.

arms before and after
Fat process

Clinical Studies on Cryolipolysis at Royal North Shore Hospital, Sydney 2016

The following results are from a Clinical Study conducted by Royal North Shore Hospital specifically on CLATUU.

“In one study with 42 patients, 79% noticed fat reduction on themselves at 2-4 months. Another study with 50 patients, 89% showed a noticeable improvement on photography with a similar proportion (80%) being happy with the results at 6 months”.

Our study showed no adverse effects associated with CLATUU cryolipolysis. Our subjects experienced an initial ‘suction’ discomfort lasting 5-10 minutes followed by cold-induced numbness for the rest of the procedure. The most common post-treatment effect was numbness lasting from 1 to 3 weeks. One patient with atopic dermatitis experienced mild itching over the treated site for a few days post-cryolipolysis.

* Results vary from person to person due to family history, age and different skin types.

Female abs

Manstein D, Laubach H, Watanabe K. Selective Cryolysis

A novel method of non-invasive fat removal. Lasers in surgery and medicine.


Excess fat poses a host of local and systemic problems. Various energy sources, for example, laser, ultrasound, and radio frequency electric current have been studied as potential non-invasive treatments aimed at local destruction of subcutaneous fat. Cryosurgery at very low temperatures is routinely used for non-specific tissue destruction, however the potential for tissue-specific cold injury has not been investigated. This study describes non-invasive cold-induced selective destruction of subcutaneous fat.

A lobular panniculitis was induced by cooling, followed for some test sites by grossly obvious loss of several mm of subcutaneous fat occurring gradually during the 3.5 months study period. Loss of adipocytes, the appearance of lipid-laden mononuclear inflammatory cells, and local thickening of fibrous septae were noted. Typically there was no clinical or histological evidence of injury to skin, and no scarring. Serum lipids were not significantly increased.


Prolonged, controlled local skin cooling can induce selective damage and subsequent loss of subcutaneous fat, without damaging the overlying skin. Selective cryolysis warrants further study as a local treatment for removal of adipose tissue.

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2008 40:595-604
woman pinched her fat on body

New England Med

Identification and importance of brown adipose tissue in adult humans.

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2009 April 9 I 360(15):1509-17Cypress A, Lehman S, Williams G.
Ice Blue Snowflake

Am J. Physiol Endocrinol Metab

The emergence of cold-induced brown adipocytes in mouse white fat deposits is predominantly determined by white to brown adipocyte transdifferentiation.

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2010 March 30–Cinti S, Barbatelli G, Murano.

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